Delicol Babies Dietary Supplement 15ml

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Opium alkaloids are extensively metabolized to glucuronide conjugates (3-glucuronide (M3G) and 6-glucuronide (M6G)) that undergo an enterohepatic cycle. 6-glucuronide is a metabolite of morphine about 50 times more active than the parent substance. Due to the ethanol content, Dropizol should not be used concomitantly with disulfiram or metronidazole. Both of these drugs can cause disulfiram-like reactions (flushing, rapid breathing, tachycardia). Because of these risks, concomitant prescribing with these sedative medicines should be reserved for patients for whom alternative treatment options are not possible. If a decision is made to prescribe Dropizol concomitantly with sedative medicines, the lowest effective dose should be used, and the duration of treatment should be as short as possible. Rifampicin induces CYP 3A4 in the liver thus increasing the metabolism of morphine, codeine and methadone. The effect of these opioids is thereby decreased or counteracted. Dropizol drops should be used with caution in the following conditions / for the following patients

Should only be used with caution in patients in high-risk groups, such as patients with epilepsy and hepatic disease. Morphine may precipitate coma in hepatic impairment – avoid or reduce dose. See Sections 4.3 and 4.4. Opium is excreted in human milk, where it reaches higher concentrations than in maternal plasma. A decision must be made whether to discontinue breast-feeding or to discontinue/abstain from Dropizol therapy taking into account the benefit of breast feeding for the child and the benefit of therapy for the woman. If Dropizol is used during breastfeeding, infants should be closely monitored for symptoms of respiratory depression and sedation. The posology should be individualized to use the lowest effective dose for the shortest duration of time taking into account the patient's general condition, the patient's age, weight, and medical history (see sections 4.3 and 4.4).

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Codeine is metabolized to give codeine-6-glucuronide, morphine (the only active metabolite) and norcodeine. Since codeine is present in opium extract at levels ten times lower than those of morphine, its hepatic transformation has little effect on the overall bioavailability of morphine. Avoid use in older adults with a history of falls or fractures as ataxia, impaired psychomotor function, syncope, and additional falls may occur. If use is necessary, consider reducing use of other CNS-active agents that increase risk of falls and fractures and implement other strategies to reduce risk of falls. Repeated administration may cause dependence and tolerance and the use of opium may lead to addiction to the substance. Particular caution should be exercised in individuals predisposed to addiction to narcotics and alcohol.

Adjustment of dose may be needed in the elderly, patients with thyroid insufficiency, and patients with mild to moderate renal or hepatic impairment (see also section 4.2 and 4.3).Peak serum concentrations of morphine, the main alkaloid of the opium extract, are achieved within 2 to 4 hours after oral administration. Dropizol is not recommended during pregnancy unless the benefits clearly outweigh the risks to both mother and child. Delicol, както всяко друго лекарство, може да предизвика нежелани реакции. Все пак трябва да се помни, че те няма да се появят на всеки и че обикновено ползите от употребата на препарата надвишават възможните рискове, свързани със страничните ефекти. Vì vậy, bổ sung enzyme lactase sẽ đem lại nhiều lợi ích trong việc cải thiện các tình trạng dưới đây: 1.1. Kém hoặc không dung nạp Lactose Delicol. Жените, които са бременни или планират да забременеят, трябва да се консултират предварително с лекаря си. Delicol – взаимодействия

Concurrent administration of morphine and antihypertensive drugs may increase the hypotensive effects of antihypertensive agents or other drugs with hypotensive effects. Treatment should be initiated and supervised by a specialist, i.e. oncologist or gastroenterologist. Elimination is reduced and delayed in renal impairment - avoid or reduce dose. See Sections 4.3 and 4.4. Opioid peptides modify the gastrointestinal (GI) function by interaction with opioid receptors on the enteric circuitries that control motility and secretion. Opioid receptors have been localized in the GI tract of humans, but their relative distribution varies with GI layer and GI region1.Anti-diarrheals inhibiting peristalsis should be used with caution in patients with infection or inflammatory bowel diseases due to the increased risk of absorption of toxins, and of developing toxic megacolon and intestinal perforation. Due to the risk of paralytic ileus, Dropizol is not recommended before a surgical operation or within 24 hours after operation. If paralytic ileus is suspected during the use of Dropizol, the treatment must be stopped immediately.