BROQ - The Gold Standard of Sulforaphane Supplements - More Than 2X Any Other Product - See Independent Lab Tests - The World’s Only High Potency Natural Stabilized Sulforaphane - Same as Prostaphane

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Keep in mind that these studies use a concentrated form of sulforaphane, so it’s unclear whether the amounts found in fresh foods have the same effect. Below is a list of the sulforaphane supplements tested and used by Jed Fahey’s team at John Hopkins University in their clinical studies:

While sulforaphane is safe in the amounts typically found in food, there is insufficient research to determine the safety of sulforaphane supplements during pregnancy or breastfeeding. We don't know anything for certain but researchers believe that it works by reducing inflammation, oxidative stress, and other processes involved in ASD. Here's a quote from a paper: Number two is how sulforaphane improves detox capacity. Sulforaphane is one of the few natural compounds that works in all three phases of detoxification, which is a process that happens in every cell of the body. But while it works in all three phases, it’s the most potent phase two detoxifier of any currently known natural compound. This is critical because for safe and efficient detoxification, a toxin should move through a relatively slow phase one reaction, followed by a more rapid phase two reaction. During phase one, toxins are oxidized, reduced, or hydrolyzed into new metabolites and can be more effectively removed by the body. During phase two, these metabolites are conjugated into less toxic compounds. One of the biggest mistakes that can be made in a detox program is upregulating phase one without also upregulating phase two. This can lead to a buildup of toxic metabolites from the phase one reaction, which can make the situation worse rather than better. Unfortunately, this isn’t uncommon because many of the compounds that people typically consume for detox, like glutathione, folate, and niacin, stimulate phase one reactions but don’t increase phase two reactions. And this is why sulforaphane is so helpful for detoxification. It balances the effects of other compounds that are typically used for detox by increasing phase two reactions and preventing the buildup of toxins and their metabolites.

I've tried a lot of supplements over the years trying to find something that can help me with my asperger's/social anxiety. I feel obligated to tell you guys about sulforaphane because I've had great results with it. Sulforaphane prevents angiotensin II-induced cardiomyopathy by activation of Nrf2 via stimulating the Akt/GSK-3ß/Fyn pathway” published in Redox Biology Despite their growing popularity, more research is needed to determine the ideal dose, safety, and effectiveness of sulforaphane supplements in humans ( 14). Summary Let’’ move on to supplements. As I mentioned earlier, the problem here is that the vast majority of supplements on the market don’t have any sulforaphane in them at all. They contain sulforaphane precursors, like sulforaphane glucosinolate, which requires the enzyme myrosinase to be converted into sulforaphane. While some people do have gut flora that produce myrosinase, others don’t. And even when they do, the conversion is really inefficient. As we talked about, it ranges from 1 to 40 percent, but the average is only 5 to 10 percent. And that’s not enough to induce Nrf2, which is the primary mechanism for sulforaphane’s benefits. Now, some companies put myrosinase into the supplement capsule, along with the sulforaphane precursors. And these products will say something like “with myrosinase” on the label. The idea is that by putting myrosinase in the capsule, it will convert the precursors into active sulforaphane. But this doesn’t appear to work very well. Two clinical trials that used the supplement with myrosinase in the capsule failed to show benefits despite sulforaphane’s well-established effects for the conditions that were being studied.

Raw vegetables have the highest levels of sulforaphane. One study found that raw broccoli had ten times more sulforaphane than cooked broccoli ( 2).That said, there is no conclusive research to confirm this yet. Does Sulforaphane Cause Weight Gain? Sulforaphane is 80 times more bioavailable than known detoxifying compounds. In this episode of RHR, we’ll discuss how you can incorporate sulforaphane into your diet and supplementation regimen to protect yourself and your family from environmental toxins, cancer, and disease. #sulforaphane #chriskresser Sulforaphane Is 80 Times More Bioavailable Than Known Detoxifying Compounds

To optimize your intake of sulforaphane, eat vegetables raw or cooked at temperatures below 284˚F (140˚C) ( 4). Another potential mechanism for sulforaphane’s protection against COVID-19 is TMPRSS2. Here we go with the acronyms again. [It’s] a protein on the cell membrane that activates viral spike proteins. So this is relevant to SARS-CoV-2 because it uses the ACE2 receptor for entry into the cell, and its spike protein is primed by TMPRSS2. Sulforaphane has been shown to decrease the expression of TMPRSS2, which then results in less surface protein to activate the binding of the virus to the human cell. So, while more research definitely needs to be done to confirm that these proposed mechanisms actually translate into real clinical benefit, sulforaphane is a promising potential intervention for COVID-19, and I look forward to seeing the results of the studies that are already underway. Prior to the introduction of BROQ, the best alternative to Prostaphane was a product by Nutramax Laboratories called Avmacol. It contains glucoraphanin (sulforaphane glucosinolate) extracted from broccoli seeds, alongside the activation enzyme myrocinase.

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Tahata S, Singh SV, Lin Y, Hahm ER, et al. Evaluation of biodistribution of sulforaphane after administration of oral broccoli sprout extract in melanoma patients with multiple atypical nevi. Cancer Prev Res (Phila). 2018;11(7):429-438. doi:10.1158/1940-6207.CAPR-17-0268

If you’re taking sulforaphane regularly, keep your bottle in a cool place away from direct sunlight. However, you can also keep it refrigerated after opening to preserve its potency. Does Sulforaphane Harm the Thyroid Gland? Each bottle contains 60 capsules. The serving size is 2 capsules, so it will last one month. Each serving gives you 20 mg of active sulforaphane. Peroxisome proliferator-activated receptor– Regulator of adipogenesis and central integrator of glucose metabolism, energy homeostasis and skeletal metabolism.Vermeulen M, Klöpping-Ketelaars IW, van den Berg R, Vaes WH. Bioavailability and kinetics of sulforaphane in humans after consumption of cooked versus raw broccoli. J Agric Food Chem. 2008;56(22):10505-10509. doi:10.1021/jf801989e Sulforaphane, which showed negligible toxicity, was selected because it upregulates genes that protect aerobic cells against oxidative stress, inflammation, and DNA-damage, all of which are prominent and possibly mechanistic characteristics of ASD." My experience Granted, I know supplements work on everyone differently but if you're struggling with typical aspie issues like having difficulty socializing, etc. this supplement is worth a try. Broq uses chemical solvents to extract sulforaphane from broccoli seed. While they do have more sulforaphane in the capsule than broccoli, 10 milligrams versus 5 [milligrams], their product does not contain any of the other beneficial isothiocyanates like erucin. All of the Johns Hopkins research on sulforaphane uses broccoli sprout beverages made, tested, and ingested on the same day. In those beverages, there are numerous isothiocyanates and not just sulforaphane. Studies have shown that erucin and another isothiocyanate called (eberron? 24:36) comprise up to 25 percent of the glucosinolate content of broccoli, with sulforaphane comprising the other 75 percent. Researchers recently discovered that erucin and sulforaphane are interconvertible, which suggests that the clinical effects observed in studies using broccoli spout beverages are likely to be due to the combined effects of all isothiocyanates, not just sulforaphane. Broccoli uses a natural water extraction process, which extracts all of the isothiocyanates from the broccoli seed. This makes taking broccoli the closest you can get to the effects of consuming the broccoli sprout beverages that have been used in the vast majority of sulforaphane studies. But in fact, I think taking broccoli is significantly better than consuming broccoli sprouts. Undiagnosed 31-year-old male aspie here. I write about supplements for a living and have read thousands of research studies on various supplement ingredients.